Grants Funded in 2005

Principal Investigator:  Arsenescu, Razvan I., M.D.
Proposal No. IBD-0168R
Applicant Organization:  University of Kentucky Research Foundation, Inc. (U.S.A.)
Project Title:  Adiponectin in Crohn's disease.  Phenotype-genotype correlations and implications in management.
Period of Award:  December 1, 2005 - May 31, 2008
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Principal Investigator:  Bianchi Porro, Gabriele, M.D.
Proposal No. IBD-0152
Applicant Organization:  L. Sacco University Hospital (Italy)
Project Title:  A new sonographic Crohn’s disease activity index based on perfusion rate and elasticity score of the affected bowel walls. Validation through repeated bowel ultrasound measurements.
Period of Award:  September 1, 2006 – August 31, 2007
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Principal Investigator:  Danese, Silvio, M.D.
Proposal No. IBD-0140
Applicant Organization:  Catholic University of Rome (Italy)
Project Title:  Angiogenesis in inflammatory bowel disease:  the contribution of platelet-endothelial interactions and implications for novel therapeutic approaches
Period of Award:  February 1, 2005 – February 28, 2007
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Principal Investigator:  Duchmann, Rainer, M.D.
Proposal No. IBD-0143
Applicant Organization:   Charité - Universitätsmedizin Berlin; Campus Benjamin Franklin (Germany)
Project Title:   CD4+CD25+ T regulatory cells in inflammatory bowel disease
Period of Award:  May 15, 2005 – August 14, 2007
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Principal Investigator:  Ebert, Ellen C., M.D.
Proposal No. IBD-0137R
Applicant Organization:  University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School (U.S.A.)
Project Title:  The role of human tropomyosin 5 in the destruction of intestinal epithelial cells in ulcerative colitis:  clinical implications
Period of Award:  March 1, 2005 – August 31, 2007
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Principal Investigator:  Hugot, Jean-Pierre, M.D., Ph.D.
Proposal No. IBD-0132R
Applicant Organization:  Naturalia et Biologia (France)
Project Title:  Identification and genetic analysis of the genes coding for CARD15 interacting proteins
Period of Award:  February 1, 2005 – October 31, 2006
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Principal Investigator:  Kirkwood, Carl D., Ph.D.
Proposal No. IBD-0167
Applicant Organization:  Murdoch Childrens Research Institute (Australia)
Project Title:  Does a viral agent induce Crohn's disease?  A search for viral agent(s) in children with early onset Crohn's disease.
Period of Award:  November 1, 2005 – April 30, 2008
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Principal Investigator:  Levitt, Michael D., M.D.
Proposal No. IBD-0151
Applicant Organization:  Minnesota Veterans Research Institute (U.S.A.)
Project Title:  Cause of the increased hydrogen sulfide production observed in inflamed ileal pouches of subjects with ulcerative colitis
Period of Award:  July 15, 2005 – January 14, 2007
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Principal Investigator:  Li, Xuhang, Ph.D.
Proposal No. IBD-0119R2
Applicant Organization:  Johns Hopkins University (U.S.A.)
Project Title:  Initial proteomic studies of inflammatory bowel diseases
Period of Award:  January 1, 2005 – December 31, 2007
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Principal Investigator:  Mizoguchi, Atsushi, M.D., Ph.D.
Proposal No. IBD-0160
Applicant Organization:  Massachusetts General Hospital (U.S.A.)
Project Title:  Therapeutic approach using interleukin-22 in experimental colitis
Period of Award:  November 1, 2005 – April 30, 2008
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Principal Investigator:  Monteleone, Giovanni, M.D., Ph.D.
Proposal No. IBD-0154R
Applicant Organization:  University Tor Vergata of Rome (Italy)
Project Title:  Interleukin-21 triggers inflammatory signals in the gut.  Relevance for human inflammatory bowel diseases.
Period of Award:  July 1, 2005 – June 30, 2007
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Principal Investigator:  Ramakrishna, Balakrishnan S., Ph.D.
Proposal No. IBD-0107R2
Applicant Organization:  Christian Medical College Vellore Association (India)
Project Title:  Is the increasing evidence of Crohn's disease in a low prevalence area associated with reduced exposure to infection with helminths?
Period of Award:  March 1, 2005 – February 28, 2007
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Principal Investigator:  Rosenberger, Carrie, Ph.D.
Proposal No. LSRF-01
Applicant Organization:  Life Sciences Research Foundation postdoctoral fellowship award to the Institute for Systems Biology (U.S.A.)
Project Title:  Role of endogenous toll-like receptor ligands in inflammatory bowel disease
Period of Award:  June 1, 2005 – November 30, 2007
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Principal Investigator:  Spiller, Robin, M.D.
Proposal No. IBD-0086R2
Applicant Organization:  University of Nottingham (United Kingdom)
Project Title:  Altered enteric nerve phenotype and visceral sensation in inflammatory bowel disease
Period of Award:  August 1, 2005 – January 1, 2007
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Principal Investigator:  Suskind, David L., M.D.
Proposal No. IBD-0153R2
Applicant Organization:  Children's Hospital and Regional Medical Center (U.S.A.)
Project Title:  Maternal microchimerism in inflammatory bowel disease
Period of Award:  October 1, 2005 – September 30, 2007
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Principal Investigator:  Török, Helga-Paula, M.D. (replacement PI); Folwaczny, Christian, M.D. (original PI)
Proposal No. IBD-0126R2
Applicant Organization:  Klinikum der Universität München (Germany)
Project Title:  NOD2/CARD15 mutations and apoptosis in Crohn's disease
Period of Award:  July 1, 2005 – March 31, 2007
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Principal Investigator:  van Eden, Willem, M.D., Ph.D.
Proposal No. IBD-0159
Applicant Organization:  Utrecht University (The Netherlands)
Project Title:  Heat shock proteins as therapeutic agents for inflammatory bowel disease
Period of Award:  September 1, 2005 – February 29, 2008
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Principal Investigator:  Zasloff, Michael, M.D., Ph.D.
Proposal No. IBD-0148R
Applicant Organization:  Georgetown University (U.S.A.)
Project Title:  Antimicrobial peptide expression and its relationship to commensal bacteria in the transplanted small bowel
Period of Award:  July 25, 2005 – July 31, 2008
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