Grant Publications

Proposal No. IBD-0154R
Principal Investigator:  Giovanni Monteleone, M.D., Ph.D.
Applicant Organization:  University Tor Vergata of Rome (Italy)
Project Title:  Interleukin-21 triggers inflammatory signals in the gut.  Relevance for human inflammatory bowel diseases.
Period of Award:  July 1, 2005 – June 30, 2007

Monteleone G, Caruso R, Fina D, Peluso I, Valentina G, Stolfi C, Fantini MC, Caprioli F, Tersigni R, Alessandroni L, MacDonald TT, Pallone F.  Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21.  Gut 2006;55:1774-80.

Caruso R, Fina D, Peluso I, Fantini MC, Tosti C, Del Vecchio Blanco G, Paoluzi OA, Caprioli F, Andrei F, Stolfi C, Romano M, Ricci V, MacDonald TT, Pallone F, Monteleone G.  IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis.  Journal of Immunology 2007;178:5957-65.

Caruso R, Fina D, Peluso I, Stolfi C, Fantini MC, Gioia V, Caprioli F, Del Vecchio Blanco G, Paoluzi O, Macdonald T, Pallone F, Monteleone G.  A functional role for interleukin-21 in promoting the synthesis of the T cell chemoattractant, MIP-3α, by gut epithelial cells.  Gastroenterology 2007;132:166-75.

Fantini MC, Monteleone G, Macdonald TT.  New players in the cytokine orchestra of inflammatory bowel disease.  Inflammatory Bowel Diseases 2007;13:1419-1423.

Fantini MC, Rizzo A, Fina D, Caruso R, Becker C, Neurath MF, MacDonald TT, Pallone R, Monteleone G. IL-21 regulates experimental colitis by modulation the balance between Treg and Th17 cells.  European Journal of Immunology 2007;37:3155-63.

Fina D, Caruso R, Pallone F, Monteleone G.  Interleukin-21 (IL-21) controls inflammatory pathways in the gut.  Endocrine, Metabolic & Immune Disorders - Drug Targets 2007;7:288-91.

Fina D, Fantini MC, Pallone F, Monteleone G.  Role of interleukin-21 in inflammation and allergy.  Inflammation & Allergy Drug Targets 2007;6:63-8.

Peluso I, Fantini MC, Fina D, Caruso R, Boirivant M, MacDonald TT, Pallone F, Monteleone G.  IL-21 counteracts the regulatory T cell-mediated suppression of human CD4+ T lymphocytes.  Journal of Immunology 2007;178:732-9.

Fina D, Caruso R, Sarra M, Del Vecchio Blanco G, Pallone F, MacDonald TT, Monteleone G.  Interleukin-21 contributes to the mucosal T helper cell type 1 response in celiac disease.  Gut 2008;57:887-92.

Fina D, Sarra M, Fantini MC, Rizzo A, Caruso R, Caprioli F, Stolfi C, Cardolini I, et al.  Regulation of gut inflammation and Th17 cell response by interleukin-21.  Gastroenterology 2008;134:1038-48.

Monteleone G, Pallone F, MacDonald TT.  Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses.  Trends in Immunology 2008;29:290-7.